Using highly optimized code for QCD on Blue Waters we have carried out calculations of major importance in high energy and nuclear physics. We generated gauge configurations (samples of the QCD vacuum) with both the HISQ and Wilson-Clover actions. On Blue Waters we are able to reduce the masses of the up and down quarks to the value they have in Nature. These leads to a major improvement as we no longer have to extrapolate in quark masses. Smaller lattice spacings of 0.042 and 0.03 fm are being used to study leptonic decays of pi, K, D, Ds, B and Bs mesons, and semileptonic decays K-> pi l nu, D-> K l nu, and D-> pi l nu. The Wilson-Clover project explores the isovector meson spectrum. Finite volume techniques are being used to determine hadron resonance parameters in the scattering of pion, kaon, and eta mesons. We computed quark propagators on $32^3 \times 256$ and $40^3 \times 256$ ensemble with 230 MeV pions. New $64^3 \times 96$ and $72^3\times 196$ ensembles will allow exploration of possible exotic meson states with energies around 2 GeV.
